The Engimatic WNT signaling and Mesenchymal stem cell Adipogenesis: Impli- cations for Metabolic Disorders
نویسنده
چکیده
The past decade has witnessed a sudden surge in the obesity prevalence worldwide. Obesity has been linked to several chronic metabolic disorders including diabetes, hyperlipidemia and atherosclerosis. Due to this there is an immense interest in understanding the intricate aspects of adipogenesis, specifically pertaining to the study of the mechanisms through which various signaling pathways regulate adipocyte differentiation. One such enigmatic signaling pathway regulating adipogenesis is the WNT signaling Pathway. The present review focusses on the role of WNT signaling on Adipogenesis and its relationship with the development of metabolic disorders. Keywords– Adipogenesis, Mesenchymal stem cell, Metabolic disorders, Wnt signaling.
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Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat
Wnt signaling is as a major regulator of adipogenesis. It differentially regulates the fate of mesenchymal stem cells (MSC) by promoting osteogenesis and myogenesis, and inhibiting adipogenesis[1]. Its loss of function has been associated with impaired osteogenesis[2] and diverse congenital and adult cardiovascular disorders[3,4]. Our group has identified loss of function mutations in Wnt corec...
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